Zometa it is a colorless and clear solution introduced in 5 ml vial applied to the vein.
What is Zometa?
Zometa; is a colorless and clear solution applied in a vein, presented in 5 ml vial. This concentrated solution is diluted before use. Each 5 ml solution contains 4 mg of an active substance called zoledronic acid. Zometa is a strong member of the group of substances called bisphosphonates.
Zometa; colorless, is presented in packages containing 1 plastic vial sealed with a rubber stopper.
Zometa, balls are infused into the vein.
Zometa, bone metastasis (splash of cancer from the primary site to the bone) it is used to prevent bone-related events (for example, fractures) in patients who have had one, and to reduce the amount of calcium in the blood in patients whose blood calcium levels rise above normal, called tumor-related hypercalcemia. It is also used to treat multiple myeloma, a type of cancer that develops in the bone marrow, and to prevent skeletal events in patients with advanced cancer that holds the bone.
Zoledronic acid shows its effect by binding to bone and reducing the rate of bone change. This substance is used to reduce this amount if there is a very high amount of calcium in the blood due to the presence of a tumor. Tumors can accelerate normal bone change to increase the rate of calcium release from the bone. This condition is known as malignant (malignant) hypercalcemia.
Although your doctor may prescribe it to you, what exactly is “Zometa?” we can't get your answer. In this article you will learn all the details.
Zometa Side Effects
Common Side Effects
Flu-like symptoms, which include headaches and fever, fatigue, weakness, dizziness, chills and bone, joint and muscle pain. Most of these side effects do not require special treatment and their symptoms disappear within a short time (a few hours or days)
Pain in the mouth, teeth, and/or jawbone, swollen and non-healing wounds inside the mouth, numbness or a feeling of heaviness in the jaw, or the shaking of any teeth. These can be signs of bone damage (osteonecrosis) in the jaw. If you experience symptoms such as these during your treatment with Zometa or after stopping treatment, tell your doctor or dentist.
In patients receiving zoledronic acid for the treatment of osteoporosis after menopause (cutting from menstruation) irregular heartbeat [atrial fertilization (a type of beat disorder in the heart)] has been observed. Although it is still unclear whether zoledronic acid causes this irregular heart rhythm, tell your doctor if you experience these symptoms after taking zoledronic acid.
- Gastric and intestinal responses, such as vomiting, nausea and loss of appetite
- Conjunctivitis (a type of eye inflammation)
- Decreased number of red blood cells (anemia)
- Severe kidney disorder (which will be determined by your doctor with specific tests)
- Decreased calcium levels in the blood
- Bone pain, myalgia (muscle pain), arthralgia (joint pain), general body pain
Non-Public Side Effects
- Severe allergic reaction; shortness of breath, swelling mainly in the face and throat
- Hypersensitivity reactions
- Low blood pressure,
- Chest pain
- Skin reactions in the area of application (flushing and swelling), rash, itching
- High blood pressure, shortness of breath, dizziness, anxiety, sleep disorders, impaired sense of taste, tremor, tingling or numbness in the hands or feet, diarrhea, constipation, abdominal pain, dry mouth, cough
- Decrease in the number of white blood cells and blood plows
- Low levels of magnesium and potassium in the blood (Your doctor will monitor these levels and take the necessary precautions)
- • Kilosuyet
- Increased sweating
- Being sleepy.
- Blurred vision, tear, sensitivity to light in the eye
- The sudden feeling of cold that is accompanied by fainting, loosening and covering the ground
- Urticaria (itchy and rash skin reaction, hives)
- Dyspepsia (pain in the stomach, accompanied by indigestion and sourness)
- Stomatitis (fire in the mouth)
- Acute renal failure, hematuria (the presence of red blood cells in the urine), proteinuria (the presence of protein in the urine)
- Asthenia (Fatigue, exhaustion)
- Diarrhea
- Constipation
- Abdominal pain
Rare Side Effects
- As a result of low calcium level: irregular heartbeat (cardiac arrhythmia secondary to hypocalcemia)
- Slow heartbeat
- Confusion of mind
- Especially in patients who have long-term treatment for osteoporosis, an unusual fracture of the thigh bone may occur. If you feel pain, weakness, or discomfort in your thigh, hip, or groin, call your doctor, this may be an early sign of a possible fracture in the thigh bone.
- Inflammation of the lung tissue (inflammation of the tissue around the air sacs in the lungs)
- Flu-like symptoms that include joint pain and swelling
- Painful redness and/or swelling in the eye (uveitis)
- Hyperkalemia (low potassium in the blood)
- Hypernatremia (Sodium height in the blood)
- Angioedema (a sudden onset of skin and mucous membranes local edema)
- Pansytopenia (decrease in all blood cells)
- Fainting due to low blood pressure
- Severe bone, joint and muscle pain that causes loss of vision to work infrequently
- As a result of low calcium level: seizure, numbness and tetani (depending on low calcium level)
- Episcleritis (Fire of the vein episclera layer between the white winter of the eye and the inside of the eyelid)
- If you have ear pain, ear discharge, and/or ear infection, talk to your doctor. These can be signs of bone damage in the ear.
How is Zometa Used?
Zometa should only be given by healthcare professionals trained to administer bisphosphonate intravenously (i.e., intravenously). Follow all instructions given by your doctor, nurse or pharmacist carefully.
The dose usually used is 4 mg.
If you have a kidney problem, your doctor may administer a lower dose.
If you are being treated for the purpose of preventing skeleton-related events, you should take it once every 3-4 weeks Zometa infusion will be applied.
To lower your level of calcium in the blood if you are receiving treatment, normally only one for you Zometa infusion will be applied.
Your doctor will decide how often to do the procedure.
Zometa, usually infusion issued through. This application should last at least 15 minutes and should be given alone without mixing with other drugs. This group should be administered by medical personnel who have experience in the delivery of drugs into the veins.
Also, if you do not have hypercalcemia (blood calcium levels rise above normal), you may need to take calcium and vitamin D by mouth in addition every day.
Your doctor will decide when to apply the zometa to you.
Use in children/Use in the elderly
The use of Zometa in children and under 18 years of age has not been studied. Therefore, the drug is not recommended for use in children and under 18 years of age.
Zometa can be used in the elderly. There is no evidence to suggest that additional measures should be taken.
If you have kidney problems, your doctor may give you a lower dose depending on the severity of your kidney problem.
Clinical data are limited in patients with severe hepatic insufficiency. If you have liver failure, your doctor will decide the dose of Zometa you will use.
What to Do in case of Overdose?
If you have used more than you should use from Zometa ’, talk to a doctor or pharmacist.
If more Zometa has been administered than you should use, changes in serum electrolytes can occur, including abnormalities and severe kidney failure.
If you have taken Zometa in higher doses than recommended, you should be carefully monitored by your doctor. Calcium supplementation may be required through infusion.
What Should I Do When I Forget to Use Zometa?
Double dose to balance forgotten doses do not take.
In What Situations is Zometa not used?
If you are allergic to zoledronic acid or other bisphosphonates (The group of substances to which zometa belongs) or any of the auxiliaries listed at the beginning of this instruction for use by Zometa (your hypersensitivity),
• pregnant,
If you are breastfeeding your baby.
What Should Zombie Users Pay Attention to?
If you have kidney problems (or have been previously),
If you have asthma or sensitivity to acetylchal silic acid
If you have pain, swelling, or numbness in your jaw or a feeling of heaviness in “jaw” or shaking in any of your teeth (or if it has happened before). Your doctor may recommend a dental exam before starting treatment with Zometa.
If you are undergoing dental treatment or are going to have dental surgery, tell your dentist that you are undergoing Zometa treatment and inform your doctor about your dental treatment.
Especially if you are receiving long-term treatment for osteoporosis, tell your doctor about any hip, thigh or groin pain that may occur during your treatment. This may be an early sign of a possible fracture in the thigh bone.
In a small number of patients who received long-term treatment with drugs in the group called bisphosphonates, among which zoledronic acid is also the active ingredient of zometa, the, a condition has emerged that causes damage to the bone structure of the outer ear canal and is called osteonecrosis. Previously, the use of steroid-containing drugs or chemotherapy drugs, having ear infections and being exposed to ear trauma have been identified as facilitating conditions for the development of this condition.
During your treatment with Zometa, you should apply the measures that will provide adequate oral hygiene
(including regular tooth brushing) and regular dental check-ups.
If you experience any problems in your mouth or teeth, such as a toothache, toothache, or non-healing mouth injury or discharge, contact your doctor or dentist immediately, because these can be signs of a condition called jaw osteonecrosis.
Having chemotherapy and/or radiotherapy, taking steroids, having dental surgery, not undergoing regular dental exams, having gum disease, etc, patients who smoke or have previously been treated with a bisphosphonate (used in the prevention or treatment of bone diseases) may have a higher risk of developing osteonecrosis of the jaw.
Get a dental exam before your treatment with Zometa and stay away from interventional (invasive) dental procedures during your treatment. Learn about good oral hygiene and the importance of routine dental care.
Your doctor will check your response to treatment at regular intervals. Your doctor will need to perform a number of blood tests before you can give Zometa treatment.
Do not forget to take enough fluid in accordance with your doctor's instructions before infusion applications; doing so will help prevent you from becoming dehydrated.
Patients treated with Zometa occasionally reported muscle cramps, dry skin, decreased blood calcium levels (hypocalcemia) that caused a burning sensation. With severe hypocalcemia, irregular heartbeat (cardiac arrhythmia), seizure, musculoskeletal pain, risk of fracture, spasm and convulsion (tetani) have been reported. If you have hip-thigh or groin pain, tell your doctor. In some cases, hypocalcemia can be life-threatening. If you have pre-existing hypocalcemia, this condition needs to be corrected before the first dose of Zometa. You will be given calcium and vitamin D supplements.
If these warnings apply to you, even at any time in the past, please consult your doctor.
Can Zometa be Used During Pregnancy/Emfeeding?
Consult your doctor or pharmacist before using the medicine.
If you are pregnant or think you may be pregnant, tell your doctor. You should not use Zometa during pregnancy.
If you notice that you are pregnant during your treatment, consult your doctor or pharmacist immediately.
Consult your doctor or pharmacist before using the medicine.
If you are breastfeeding your baby, consult your doctor. It is not known whether zoledronic acid, the active substance of the zometa, passes into breast milk.
You should not breastfeed your baby while being treated with Zometa.
What is the Zometa Active Ingredient?
This medicinal product contains less than 5 mmol (23 mg)’ of sodium per 5 milliliters; no side effects due to this dose of sodium are to be expected.
Is Zometa Used With Other Drugs?
If you are taking one of the following medications, you may need to change the dose and/or take other measures:
Aminoglycosides in particular (a type of drug used in the treatment of severe infections), calcitonin (a type of drug used in the treatment of post-menopausal osteoporosis and hypercalcemia), such as, it is important for your doctor to know if you are taking loop diuretics (a type of medication that treats high blood pressure - hypertension or edema) or other calcium-lowering medications, because the use of these together with bisphosphonates can cause an excessive level of calcium in the blood.
If you are taking a medication known to be harmful to your kidneys, tell your doctor.
Tell your doctor if you are taking anti-angiogenic drugs (e.g.: bevacizumab) for your cancer treatment; because the combination of these drugs with bisphosphonates can increase the risk of bone damage (osteonecrosis) in your jaw.
Zometa has the same active substance (zoledronic acid) as the drug ACLASTA. If you are taking ACLASTA or other bisphosphonates (the same class of drugs), you should not use Zometa at the same time.
Vehicle and machinery use
The effects of Zometa on vehicle and machine use and other work that you need to give your full attention have not been investigated. Very infrequently it can cause drowsiness and drowsiness. Therefore, you should be careful when doing this kind of work.