What is TAZOCIN EF and what is it used for?
TASOCIN EF is an antibiotic presented in vial containing 4.5g of sterile, white to whitish color, lyophilized powder. Contains piperacillin and tazobactam. Piperacillin is included in a group known as broad-spectrum penicillin antibiotics that can kill many types of bacteria. Tazobactam prevents some bacteria from developing resistance to the effects of piperacillin. Some bacteria that cannot be killed by piperacillin can be killed when piperacillin and tazobactam are given together
TASOCIN EF will be given intravenously by injection (slow injection, 3-5 minutes) or infusion (in serum, 20-30 minutes) after the powder in the vial in your package is diluted.
In adults, TASOCIN EF is used in bacterial infections that affect body areas such as the chest cavity, urinary tract, blood, intra-abdominal or skin. TASOCIN EF can be used in patients who have problems coping with infections in conjunction with medications known as aminoglycosides to treat the infection.
in children 2-12 years of age, TASOCIN EF is used in intra-abdominal infections and in the treatment of infections that occur with a decrease in the number of neutrophils (a type of white blood cell) in the blood, accompanied by a course of fever with an aminoglycoside.
What are the Side Effects?
Like all medicines, there may be side effects in people who are sensitive to substances contained in the TASOCIN EFazine content.
Unwanted effects are listed by the following categories:
Very common:Public :
Uncommon:
Sparse:
Very rare:
> 1/10
> 1/100 to < 1/10
> 1/1000 to < 1/100
> 1/10000 to < 1/1000 < 1/10000
Infections,
Uncommon: Caused by Candida species with any infection (superinfection)
the start of a second infection
Blood and lymph system:
Uncommon: Decrease in the number of achyuvals (leukopenia), fragmented cell (neutropenia), blood plow (platelets) in the blood
Rare: Signs of anemia, bleeding (including bruising, nosebleeds, prolongation of bleeding time), an increase in the number of eosinophils (a type of allergy cell) in the blood, anemia due to clotting disorder (hemolytic anemia)
Very Rare: Decrease in the number of white blood cells, positive Coombs direct test (a blood test related to red blood cells), decrease in all cells in the blood, deterioration of tests related to the time of bleeding (extension of the time of partial thromboplastin, increased, prolongation of prothrombin time) increase in the number of platelets (thrombocytosis)
Disorders of the immune system
Uncommon: Hypersensitivity reaction Rare: Sudden hypersensitivity response including shock
Metabolism and nutritional disorders:
Very Rare: Decreased albumin in the blood, decreased blood sugar, decreased total protein in the blood, decreased blood potassium level below normal
Disorders of the nervous system
Uncommon: Headache, insomnia
Circulatory system
Uncommon: Low blood pressure, inflammation of the veins, formation of blood clots due to inflammation of the veins Infrequent: Hot flashes
Digestive system:
Common: Diarrhea, nausea, vomiting
Uncommon: Constipation, indigestion, jaundice, inflammation in the mouth (stomatitis) Rare: Abdominal pain, inflammation of the intestine with bloody, watery diarrhea due to prolonged antibiotic use
Liver-safra system
Uncommon: Increase in certain liver enzymes (increased alanine aminotransferase, increased aspartate aminotransferase)
Infrequent: Increase in bilirubin, increase in alkaline phosphatase in the blood, increase in gamma-glutamyltransferase, inflammation of the liver (hepatitis)
Disorders of the skin and subcutaneous tissue
Common: Rash
Uncommon: Itching, hives
Infrequent: Bubbly dermatitis filled with fluid (bulb dermatitis), erythema multiform (often spontaneous, causing redness similar to the hand, face and standing lace, a state of hypersensitivity)
Very Rare: Blood sitting on the skin and around the eyes, inflammation with swelling and redness (Stevens Johnson Syndrome), toxic epidermal necrolysis (a serious disease with fluid-filled blisters on the skin)
Musculoskeletal, connective tissue and bone disorders
Uncommon: Joint pain
Kidney and urinary tract disorders
Uncommon: Increased creatinine in the blood
Infrequent: Lack of appetite, excessive thirst, inflammation of the kidneys with vomiting, kidney disorder Very Rare: Increase in blood urea nitrogen
General disorders and conditions related to the place of application
Uncommon: Fever, reaction at the site of application
Rare: At the injection site, hardness due to injection
How to use TASOCIN EF?
Your doctor will determine the dose of your medication and administer it to you, depending on your disease.
Use in the elderly:
The general dosage for adults and children over 12 years of age with normal kidney function is 8 g of TAZOCIN EF every 4.5 hours. The total daily dose depends on the severity and area of the infection, and 2.25g to 4.5g OF TAZOCIN EF can be administered every six or eight hours.
Your doctor will administer TASOCIN EF’ in your vein through slow injection or serum (through infusion).
Use in children
in children under 2 years of age, TASOCIN EF is not recommended because there is not enough data.
Use in the elderly:
TASOCIN EF can be administered at the same dose as adults except for patients with renal failure.
Special Use Cases
In children aged 2-12 years with intra-abdominal infection: Kidney function is normal, weight is up to 40kg, the recommended dose in children is 8 mg/kg every 112 hours. Kidney function is applied to children whose normal weight is over 40kg in adult dose.
Decrease in the number of neutrophils in the blood seen in children: The dose for children with normal renal function and a weight of less than 50 kg of 80 mg per kg of piperacillin/for administration every 6 hours/It should be set to 10 mg of tazobactam and given together with an appropriate dose of aminoglycoside. For children with a weight of more than 50 kg, the dosage recommendations applicable to adults, in conjunction with an appropriate dose of aminoglycoside, should be followed.
Kidney Failure: The dosage should be adjusted to the extent of renal dysfunction in patients with renal failure or in patients with hemodialysis.
Liver Failure: No dose adjustments are recommended in patients with liver impairment.
If you have an impression that the effect of TAZOCIN EF’ is too strong or weak, talk to your doctor or pharmacist.
TAZOCIN EF
What to Do in case of Overdose?
If you have used more than you should use TAZOCIN EF, talk to a doctor or pharmacist.
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What Should I Do When I Forget to Use TASOCIN EF?
Do not take double doses to offset forgotten doses.
Post Treatment For Those Using TASOCIN EF
Not found.
Things to consider before using TASOCIN EF
Who Shouldn't TAZOCIN EF be Used by?
If you are sensitive (allergic) to beta-lactams (including penicillins and cephalosporins) or certain other antibiotics (such as P-lactamase inhibitors)
What Should TAZOCIN EF Users Pay Attention to?
• Severe and sometimes fatal hypersensitivity reactions have been reported in treatment with penicillins, including EF. If an allergic reaction occurs during the treatment of TASOCIN EF, antibiotic therapy should be discontinued.
• regular electrolyte detection should be performed in patients with low potassium levels. Slight elevations may be observed in liver function tests.
• Before treatment, syphilis should be investigated in patients with gonorrhea at the same time. If these warnings apply to you at any time in the past, please consult your doctor.
Food and Beverage Consumption Together With TASOCIN EF
What are the foods and drinks that are inconvenient to be consumed with the specified medication? What should we eat or not eat?
Food and Beverage Consumption Together With TASOCIN EF
What are the foods and drinks that are inconvenient to be consumed with the specified medication? What should we eat or not eat?
Is it Used During Pregnancy (Pregnancy) Period?
Consult your doctor or pharmacist before using the medicine.
Sufficient studies on the use of TAZOCIN EF’ in pregnancy have not yet been completed. Piperacillin and tazobactam pass into the placenta. In pregnant women, it should be used only if its therapeutic benefit is greater than the risk to the patient and fetus.
If you notice that you are pregnant during your treatment, consult your doctor or pharmacist immediately.
Can it be Used During Breastfeeding?
Consult your doctor or pharmacist before using the medicine.
Piperacillin passes into breast milk at low concentrations. In breastfeeding women, it should be used only if the benefit is more than the risk to the patient and the baby.
Vehicle and machinery use
It has no effect on the ability to use cars and other types of machines.
What is TASOCIN EF Active Ingredient?
This medicinal product contains 2.79 mmol (64 mg) of sodium per gram. This should be considered for patients on a controlled sodium diet.
Is It Used With Other Drugs?
• if you are using drugs that contain Probenecid (used to treat gout), blood-thinning drugs such as heparin, warfarin and aspirin, methotrexate (used to treat cancer, arthritis and psoriasis), tell your doctor about them.
• Because compatibility is not known, TASOCIN should not be mixed with other drugs in syringes or infusion bottles. When TASOCIN EF is taken with another antibiotic, the drugs should be administered separately.
• EF TAZOCIN should not be used with solutions containing sodium carbonate alone.
• EF TAZOCIN should not be added to blood products or products containing albumin.
If you are currently taking any prescription or over-the-counter medications or have recently used them, please tell your doctor or pharmacist about them.
To download the TASOCIN prospectus as a PDF file here
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