What is QUET and what is it used for?
QUET is a white, oblong, biconvex film-coated tablet with a face notched. QUET 400 mg is offered in box, in opaque PVC/A1 foil blister package as 30 or 60 tablets.
QUET is a drug belonging to the group of drugs, the active substance of which is quetiapine, called antipsychotics (drugs used in the treatment of psychiatric diseases).
This group of drugs is effective in the treatment of certain psychiatric diseases, such as:
Hallucinations (such as hearing inexplicable sounds), strange and frightening thoughts, changes in behavior and thought, and states of confusion, including,
Extreme enthusiastic or excited mood. People in this mood; they need less sleep than usual, they are more talkative, they may notice that thoughts or ideas flow quickly. These people may be unusually nervous.
The grieving feeling situation. People with this mood may feel pessimism, guilt, loss of energy, decreased appetite and/or insomnia.
When your doctor feels better, they may continue to give you QUET to prevent the symptoms from recurring.
It may be helpful to tell a friend or relative that you are uncomfortable with these symptoms and ask them to read this instruction. If they think your symptoms are getting worse or are concerned about other changes in your behavior, you can ask them to tell you about it.
What are the Side Effects?
Like all drugs, there may be side effects in people who are sensitive to substances contained in the QUETin content.
Very common (> 1/10)
Dizziness (can cause fainting), headache, dry mouth, etc,
Very pronounced sleepiness
Symptoms that occur with discontinuation of the drug (vomiting, dizziness, nausea, headache, diarrhea, discontinuation of the use of QUET, such as insomnia and restlessness. A gradual discontinuation of the drug is recommended for a period of one to 2 weeks).
Weight gain
Decrease in blood count (Diminished hemoglobin)
Increase in blood lipid levels (Increased serum triglyceride levels)
Increase in blood cholesterol levels
Decrease in HDL cholesterol levels Common (>1/100 to <1/10)
Increase in heart rate (tachycardia),
Feeling like the heart is pounding too strong, beating too fast or jumping between heartbeats,
Nasal congestion,
Constipation, stomach disorder (indigestion)
Feelings of weakness and powerlessness, and,
• shit on arms or legs,
• When you get up to the feet, the blood pressure drops (orthostatic hypotension) and, accordingly, the feeling of dizziness or fainting (can cause fainting),
Elevation of blood sugar,
Blurred vision, the,
Abnormal muscle movements, such as difficulty with the onset of muscle movements, tremors, discomfort or painless muscle retention, etc,
Abnormal dreams and nightmares,
Feelings of hunger (increased appetite),
Being hypersensitive to stimuli
Difficulty in speech and pronunciation,
Increased depression and suicidal thoughts,
- stenosis of the feet,
Vomiting (especially in the elderly),
Fever
Increase and decrease in white blood cells (Diminished leukocyte count in blood, decrease in neutrophil count, increase in eosinophilia),
Increase and decrease in hormone levels (Elevation of prolactin levels in blood, decrease in total T4’, decrease in free T4’, decrease in total T3’, increase in the level of the hormone that inhibits the growth and function of the thyroid gland), etc,
Increase in liver function tests (elevation in serum transaminase levels, gamma-
Elevation of GT levels),
Swelling in the joints and soft tissue (peripheral edema).
Uncommon (>1/1000 to < 1/100)
Seizures,
Allergic reactions, such as severe skin rash, blisters on the skin and swelling on the skin, etc,
Restless legs syndrome, the,
Difficulty swallowing
Involuntary movements (tardive dyskinesia), especially in percentage and language,
Disorder in sexual activity
The worsening of pre-existing diabetes (sugar disease),
Change in the electrical activity of the heart (QT elongation), seen in the ECG,
Increased and decrease in blood count and blood cells (increase in the number of platelets in the blood, anemia, decrease in the number of blood plows),
Decrease in blood hormone levels (decrease in free T3’ hypothyroidism),
Lowering the level of sodium in the blood below normal, diabetes
Infrequent (>1/10000 to < 1/1000)
A combination of fever, very pronounced dizziness, hardening of the muscles, a significant increase in blood pressure or pulse and a decrease in awareness (a disorder called “neuroleptic malignant syndrome”),
Diabetes is a metabolic disorder (metabolic syndrome), consisting of heart attack risk factors such as obesity in the abdomen, impaired blood fat levels, high blood pressure,
Yellowing in the skin and eyes (jaundice),
Inflammation of the liver (hepatitis),
Priapism (long-lasting and painful erection)
Swelling in the breasts and unexpectedly producing breast milk (galactorrhea)
Menstrual irregularity
Blood clotting in the leg veins, especially moving along the lungs to cause chest pain and difficulty breathing (swelling in the legs, signs of pain and redness). If any of these symptoms occur, contact your doctor immediately.
Walking, talking, eating and other activities while sleeping,
Decrease in body temperature (hypothermia),
Inflammation of the pancreas
Reduction or inability to make red blood cells in the blood (agranulocytosis),
Blockage of capillaries with clots,
Increase in liver function tests (increased blood creatine phosphokinase levels)
Very infrequent (< 1/10000)
Severe puffiness, fluff and red blisters on the skin.
Severe allergic reactions that can cause breathing difficulties or shock (Anaphylaxis), including,
Sudden blistering of the skin, especially around the eyes, lips and throat (Angyoedema)
Improper secretion of the hormone that regulates the volume of urine
• Rupture of muscle fibers and pain in muscles (Rabdomyolysis)
Decrease in hormone levels that regulate blood pressure (inappropriate antidiuretic hormone secretion), including,
Diffuse body inflammation (Stevens-Johnson syndrome), which involves skin, skin, blood cells, causing the body defense system to collapse, testing for sudden vital functions
Unknown (unpredictable from the data at hand)
Skin rash (eritema multiforme), with irregular red spots,
Severe, sudden allergic reaction (toxic necrolysis), in which symptoms such as fever, formation of blisters on the skin and peeling of the skin,
In newborn babies due to prolonged release of quetiapine of pregnant women, restlessness, excessive tension of muscles, loss of tension of muscles, tremor, sleepiness, mood, signs of drug withdrawal, such as difficulty breathing or nutritional disorders (newborn drug withdrawal syndrome),
Decreased blood cells (neutropenia).
The group of drugs, including QUETin, can cause heart rhythm disorders that can result in severe and death.
Some side effects can only be seen when a blood test is done. These include an increase in the amount of certain fats (triglycerides and total cholesterol), an increase in the amount of sugar in the blood, changes in the amount of thyroid hormones in the blood, an increase in liver enzymes, a decrease in the number of certain blood cells, a decrease in the amount of red blood cells, a decrease in the amount of red blood cells, blood creatine can be seen as an increase in the amount of phosphokinase (a substance in the muscles) and an increase in the amount of the hormone called prolactin in the blood. Increases in the hormone prolactin can infrequently cause the following conditions:
Swelling in the breasts in men and women and unexpectedly producing breast milk
Lack of menstrual bleeding in women or irregular
Children and adolescents:
Some of the side effects that can be seen in adults can also occur in children and adolescents: The following side effects occur only in children and adolescents.
Very common (> 1/10)
Increase in blood pressure.
The following side effects are more common in children and adolescents.
Very common (> 1/10)
Increased hormone prolactin in the blood. Rarely, this can lead to the following consequences:
Swelling in the breasts in boys and girls and unexpectedly producing breast milk
The fact that girls do not have monthly periods or experience irregular periods
Increased feeling of hunger
Abnormal muscle movements such as difficulty in starting muscle movements, tremors, discomfort or muscle tension without pain
Common (> 1/100 to <1/10)
Sensitivity to stimuli
How is QUET Used?
Always follow your doctor's instructions strictly when using QUETi.
Ask your doctor or pharmacist if you are unsure.
Your doctor will decide what your starting dose will be and how many tablets of QUET you take each day.
The QUET tablet is for oral use only.
• You will usually receive your tablets twice a day.
• Swallow your tablets whole, with some water.
Do not stop taking the tablets even if you feel good without your doctor telling you.
If you suddenly stop using QUET, you may develop nausea or vomiting or suffer from insomnia.
do not drink grapefruit juice while taking QUET treatment. It can change the way the medicine acts.
Use in children and adolescents:
When using QUETi in children and adolescents, always follow your doctor's instructions with certainty. Ask your doctor or pharmacist if you are unsure.
Your doctor will decide what your starting dose will be and how many tablets of QUET you take each day.
Use in the elderly:
It should be used with caution in the elderly, especially during the initial period of treatment. In elderly patients, treatment should be started with a low dose of 25 mg and then the dose should be increased slowly.
Special Use Cases
In patients with renal insufficiency, there is no need to adjust the dose.
QUET should be used with caution in patients known to have hepatic insufficiency, especially in the initial period of treatment. Treatment should be started with a low dose, 25 mg, then the dose should be increased slowly.
If you have an impression that the effect of QUETidine is very strong or weak, talk to your doctor or pharmacist.
QUET
What to Do in case of Overdose?
If you have used more than you should use QUET, talk to a doctor or pharmacist immediately.
In this case, you may experience drowsiness, lightheadedness, and abnormal heartbeats.
What Should I Do When I Forget to Use QUET?
Do not take double doses to offset forgotten doses.
Take the tablet you forgot, as long as it is not too close to the time of taking the next dose, as soon as you remember.
things to consider before using QUET
who Shouldn't QUET be Used by?
If you are hypersensitive to the active ingredient quetiapine or any component of QUETin (see list of auxiliary substances), (allergy),
If you are taking any of the following medications:
o Certain drugs used in the treatment of HTY (HIV-protease inhibitors such as didanosine, lopinavir, ritonavir)
o Azole class drugs used against fungal infections (such as ketoconazole, fluconazole, itraconazole)
o Some medications such as erythromycin, clarithromycin used in the treatment of infections certain depression drugs such as nefazodone
In case of severe central nervous system depression, bone marrow suppression, blood dyscrasia, a blood-related disease, severe liver disease and coma.
What Should QUET Users Pay Attention to?
If you are depressed and/or have another psychiatric illness, thoughts of self-harm or suicide may sometimes arise.
Information from clinical trials in children, young or young adults, children treated with antidepressants, suicidal ideation in young and young adults under 25 years of age and/or it has shown an increase in suicidal behavior.
QUET is not approved in children under the age of 18 with Bipolar Depression and in adolescents.
If suicidal thoughts or behaviors or thoughts of harming yourself occur, contact your doctor immediately.
If you have heart disease,
■ If your blood pressure is low.
If you have had ■ strokes and are especially old,
If you have passed ■ remittance (convulsions), you,
■ If you feel discomfort in the arms, legs, you,
■ Especially if you have out-of-control movements on your face and tongue,
■ If you have fever, confusion and muscle stiffness in the mind, you,
■ If your number of aquaria has been found low for any reason that has been caused by drugs in the past or has nothing to do with them.
■ If you have diabetes (diabetes) or a risk of having diabetes, blood sugar elevation and hyperglycemia (high blood sugar) have been observed in studies with quetiapine. If you are at risk of diabetes (such as diabetes from the family, high blood sugar seen in pregnancy), you should report this condition to your doctor. If you have diabetes, you should be under follow-up to prevent your diabetes from getting worse
If your blood fats (triglycerides) and cholesterol levels are high, you,
■ Since this group of drugs is associated with the formation of blood clots, if you or your family have a history of blood clots in the vein, you can,
■ If you have a problem with liver.
■ If you have difficulty swallowing.
■ If you have cataract disease.
If this applies to you even at any time in the past, please
consult your doctor.
If any of the following symptoms apply to you immediately after using QUETi
consult your doctor.
A co-existence of fever, severe muscle retention, sweating and loss of consciousness, known as neuroleptic malignant syndrome. For this, urgent medical treatment may be required.
Mostly uncontrolled movements on the face or tongue,
Dizziness or feeling seriously sleepy. This may increase the risk of injury (fall) due to accidents in elderly patients.
Seizures,
Prolonged and painful erection (priapism).
Suicidal thoughts and worsening of your depression
If you are depressed, you may have thoughts of harming yourself or killing yourself from time to time. Such thoughts may increase when treatment is first started. This is because these types of medications usually provide benefits within 2 weeks or sometimes longer. Such thoughts can also increase if you suddenly stop taking the drug.If you are a young adult, you are more likely to have such thoughts. Information from clinical studies suggests that the risk of suicidal thoughts and/or suicidal behavior increases in younger adults under the age of 25 with depression.
If you have thoughts of harming or killing yourself at any time, tell your doctor or go to a hospital. It may be helpful to tell a friend or someone you are depressed and ask them to read this instruction. If they think your symptoms are getting worse or are concerned about other changes in your behavior, you can ask them to tell you about it.
Food and Beverage Consumption Together With QUET
What are the foods and drinks that are inconvenient to be consumed with the specified medication? What should we eat or not eat?
You can take QUETi with or separately from food.
It should be taken with alcohol. Because the combined effects of QUET and alcohol can make you sleepy.
do not drink grapefruit juice while taking QUET treatment. It can change the way the medicine acts.
Is it Used During Pregnancy (Pregnancy) Period?
consult your doctor or pharmacist before using the medicine.
QUET should only be used when absolutely necessary during pregnancy, if the benefit exceeds the potential risk to the baby.
In the third trimester of pregnancy, newborns exposed to antipsychotic drugs (effective in the treatment of psychiatric diseases such as schizophrenia, psychotic depression), abnormal muscle movements and/, which may change in severity following childbirth/or they are at risk for signs of drug withdrawal. These symptoms include restlessness, excessive tension of the muscles, loss of tension in the muscles, tremors, sleepiness, difficulty breathing or nutritional disorders. If your baby develops any of these symptoms, you should contact your doctor.
If you notice that you are pregnant during your treatment, consult your doctor or pharmacist immediately.
Can it be Used During Breastfeeding?
Consult your doctor or pharmacist before using the medicine.
Do not breastfeed your baby during the time you use the medicine.
Vehicle and machinery use
This medicine you use can bring your sleep. Do not use tools or machines before you know how these tablets affect you.
What is QUET Active Agent?
QUET contains lactose, a type of sugar. If your doctor has told you that you have an intolerance to certain sugars, consult your doctor before taking this medicine.
QUET contains less than 1 mmol (23 mg)’ in each dose; that is, it does not actually contain “sodium. No adverse effects due to the amount of sodium are expected.
Is It Used With Other Drugs?
In particular, if you are taking the following medications, tell your doctor:
Medications to treat anxiety or depression (such as imipramine.fluoxetine)
Sara (epilepsy) drug such as phenytoin or carbamazepine
Blood pressure medications
Drugs used for insomnia treatment (barbiturate);
Some medications used to treat AIDS (HlV-protease inhibitors such as)
Tioridazine (another antipsychotic drug).
Medications that affect heart rate, such as diuretics that make electrolyte disorders (low potassium or magnesium) or certain antibiotics
Diuretics (urine pill)
Tell your doctor if you are taking medication used to treat infection, such as the following, or if you will be discontinuing it in the near term.
Rifampicin for the treatment of tuberculosis
Ketoconazole for fungal infections
erythromycin or clarithromycin as antibiotics.
If you are currently taking any prescription or over-the-counter medications or have recently used them, please tell your doctor or pharmacist about them.
Drug screening in urine
If drug screening is performed in the urine, even if you are not using drugs called methadone or tricyclic antidepressants used for depression due to your use of QUET, some test methods may cause a positive result for these drugs. With more specific tests, the results may need to be verified.
To download the QUET prospectus as a PDF file here
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